From advanced engineering to clinical trials.

Our programs are focused on progressing gene-edited, porcine-derived organs from engineering to clinical trials, to provide life-saving transplants for patients with end-stage organ failure.

Research

Preclinical

IND Enabling

Clinical

Kidney EGEN-2784
Liver EGEN-5784 ELC
Heart EGEN-4467

“Clearance of the EGEN-2784 IND and initiation of this clinical study are important steps forward in our mission to end the global organ shortage.”

Mike Curtis, Ph.D President and Chief Executive Officer of eGenesis
View press release

Publications

The scientific foundation of eGenesis is defined by peer-reviewed research advancing the field of xenotransplantation.

December 2025 Gene-edited Pig Cardiac Xenotransplantation as a Bridge to Allotransplantation in Infants: Progress in a Pig-to-Baboon Model. Opens in a new tab.
Cleveland JD, Mitchell CB, Swicord W , et al.

National Center for Biotechnology Information
June 2025 Infectious disease surveillance and management in clinical xenotransplantation: Experience with the first human porcine kidney transplant. Opens in a new tab.
Fishman JA, El Khoury J, Kawai T , et al.

National Center for Biotechnology Information
February 2025 Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease. Opens in a new tab.
Kawai T, Williams WW, Elias N , et al.

National Center for Biotechnology Information
January 2025 Artificial Liver Support Systems in Acute Liver Failure and Acute-on-Chronic Liver Failure: Systematic Review and Meta-Analysis. Opens in a new tab.
Brown RS Jr, Fisher RA, Subramanian RM , et al.

National Center for Biotechnology Information

View all publications