Longitudinal multiomics profiling of extracorporeal cross-circulation with pig liver xenografts in human decedents. Opens in a new tab.
Guo Q, Wang C, Mauduit V
, et al.
Nature Medicine
From advanced engineering to clinical trials.
Our programs are focused on progressing gene-edited, porcine-derived organs from engineering to clinical trials, to provide life-saving transplants for patients with end-stage organ failure.
“Clearance of the EGEN-2784 IND and initiation of this clinical study are important steps forward in our mission to end the global organ shortage.”
Publications
The scientific foundation of eGenesis is defined by peer-reviewed research advancing the field of xenotransplantation.
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Simultaneous quantification of native human and transgenic porcine liver function in a decedent model of extracorporeal cross-circulation. Opens in a new tab.Abraham Shaked, Michael P. McRae, Joanne C. Imperial , et al.ScienceDirect
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Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents. Opens in a new tab.Shaked A, Sagar A, Olthoff KM , et al.Nature Medicine
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Gene-edited Pig Cardiac Xenotransplantation as a Bridge to Allotransplantation in Infants: Progress in a Pig-to-Baboon Model. Opens in a new tab.Cleveland JD, Mitchell CB, Swicord W , et al.American Journal of Transplantation