Numerous strategies to increase human donor organ supply have not closed the staggering supply-demand gap that only continues to increase. Human donor organs may never fully meet demand. Xenotransplantation is one approach that has the potential to sufficiently address the organ shortage crisis.
Xenotransplantation is the transplantation of living organs, tissues, or cells from one species to another. Pigs have been identified as a good species for xenotransplantation due to their similarity to humans in terms of organ structure and physiology, in addition to the abundance of the species.
In the past, two key hurdles have prevented successful xenotransplantation:
- The potential risk of the transmission of viruses between species
- Immune-mediated incompatibilities between species leading to organ rejection
Recent innovations in gene-editing technology enable more precise yet more feasible editing of the genome than was ever before possible.1 At eGenesis, we are harnessing this innovation to tackle both of the hurdles that have prevented the advancement of xenotransplantation to date and to create Human Compatible (HuCo™) organs and cells to address the transplant shortage crisis.